Bronchitis

Bronchitis (Chest Cold)

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Overview of Bronchitis

Acute bronchitis (brahn-KITE-uss), or chest cold, is a condition that occurs when the bronchial (BRAHN-kee-uhl) tubes in the lungs become inflamed. The bronchial tubes swell and produce mucus, which causes a person to cough. This often occurs after an upper respiratory infection like a cold. Most symptoms of acute bronchitis (chest pain, shortness of breath, etc.) last for up to 2 weeks, but the cough can last for up to 8 weeks in some people.

Chronic bronchitis lasts a long time, and is more common among smokers. People with chronic bronchitis have a cough with mucus most days for 3 months a year for 2 consecutive years. If you have been diagnosed with chronic bronchitis, you should visit a specialist to be evaluated.

Visit the American Academy of Family Physicians’ website to watch a video about bronchitis.

Another kind of lung infection that parents should know about is bronchiolitis (BRAHN-kee-oh-LIE-tus). Infants can be diagnosed with bronchiolitis, a viral infection, which can obstruct the small airways and may require treatment. Learn more about bronchiolitis by visiting the National Institutes for Health website.

Causes of Bronchitis

  • Several types of viruses, most often:
    • 1) Respiratory syncytial (sin-SIH-shull) virus (RSV)

      Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a respiratory virus that infects the lungs and breathing passages. Most otherwise healthy people recover from RSV infection in 1 to 2 weeks. However, infection can be severe in some people, such as certain infants, young children, and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia in children under 1 year of age in the United States. In addition, RSV is more often being recognized as an important cause of respiratory illness in older adults.

    • 2) Adenovirus

      Clinical features: Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis (bladder infection), and rash illness. Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. Young infants and especially patients with compromised immune systems are more susceptible to severe complications of adenovirus infection. Acute respiratory disease (ARD), which was first recognized among military recruits during World War II, can be caused by adenovirus infections.

   
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The viruses: Adenoviruses are medium-sized (90-100 nm), nonenveloped icosohedral viruses containing double-stranded DNA. There are at least 52 immunologically distinct types that can cause human infections. Adenoviruses are unusually stable to chemical and physical agents and to adverse pH conditions, thus allowing for prolonged survival outside of the body.

Epidemiologic features: Although epidemiologic characteristics of the adenoviruses vary by type, all are transmitted by direct contact, fecal-oral transmission, and occasionally waterborne transmission. Some types can establish persistent asymptomatic infections in tonsils, adenoids, and intestines of infected hosts, and shedding can occur for months or years. Some adenoviruses (e.g., serotypes 1, 2, 5, and 6) have been shown to be endemic in parts of the world where they have been studied, and infection is usually acquired during childhood. Other types cause sporadic infection and occasional outbreaks; for example, epidemic keratoconjunctivitis is associated with adenovirus serotypes 8, 19, and 37. Epidemics of febrile disease with conjunctivitis are associated with waterborne transmission of some adenovirus types, often centering around inadequately chlorinated swimming pools and small lakes. ARD is most often associated with adenovirus types 4 and 7, and more recently adenovirus 14, in the United States. Enteric adenoviruses 40 and 41 cause gastroenteritis, usually in children. For some adenovirus serotypes, the clinical spectrum of disease associated with infection varies depending on the site of infection; for example, infection with adenovirus 7 acquired by inhalation is associated with severe lower respiratory tract disease, whereas oral transmission of the virus typically causes no or mild disease. The typical incubation period for gastroenteritis is 3-10 days; for respiratory tract infections it is between 2 and 14 days Outbreaks of adenovirus-associated respiratory disease have been more common in the late winter, spring, and early summer; however, adenovirus infections can occur throughout the year.

Diagnosis: Antigen detection, polymerase chain reaction assay, virus isolation, and serology can be used to identify adenovirus infections. Adenovirus typing is usually accomplished by hemagglutination-inhibition and/or neutralization with type-specific antisera or by hexon gene sequence molecular methods. Since adenovirus can be excreted for prolonged periods, the presence of virus does not necessarily mean it is associated with disease.

Treatment: Most infections are mild and require no therapy or only symptomatic treatment. Because there is no virus-specific therapy, serious adenovirus illness can be managed only by treating symptoms and complications of the infection.

Prevention: Vaccines were developed for adenovirus serotypes 4 and 7, but were available only for preventing ARD among military recruits, however, vaccine production was stopped in 1999. Strict attention to good infection-control practices, including contact and droplet precautions, is effective for stopping nosocomial outbreaks of adenovirus-associated disease, such as epidemic keratoconjunctivitis. Maintaining adequate levels of chlorination is necessary for preventing swimming pool-associated outbreaks of adenovirus conjunctivitis, and frequent hand hygiene is recommended in group child care settings.

  • 3) Influenza

    There are two main types of influenza (flu) virus: Types A and B. Influenza A and B viruses that routinely spread in people ( human influenza viruses) are responsible for seasonal flu epidemics each year. The emergence of a new influenza virus causing illness in people can result in an influenza pandemic, as occurred in the spring of 2009 when a new influenza A (H1N1) virus emerged to cause illness in people and spread worldwide.

    Influenza A viruses can be broken down into sub-types. Over the course of a flu season, different types (A & B) and subtypes of influenza A viruses can circulate and cause illness. In addition, influenza viruses are constantly changing through a process called "antigenic drift."

    • Types of Influenza Viruses

      There are three types of influenza viruses: A, B and C. Human influenza A and B viruses cause seasonal epidemics of disease almost every winter in the United States. The emergence of a new and very different influenza virus to infect people can cause an influenza pandemic. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics.

      Influenza A viruses are divided into subtypes based on two proteins on the surface of the virus: the hemagglutinin (H) and the neuraminidase (N). There are 16 different hemagglutinin subtypes and 9 different neuraminidase subtypes. Influenza A viruses can be further broken down into different strains. Current subtypes of influenza A viruses found in people are influenza A (H1N1) and influenza A (H3N2) viruses. In the spring of 2009, a new influenza A (H1N1) virus emerged to cause illness in people. This virus was very different from regular human influenza A (H1N1) viruses and the new virus caused the first influenza pandemic in more than 40 years.

      Influenza B viruses are not divided into subtypes. Influenza B viruses also can be further broken down into different strains.

      Influenza A (H1N1), A (H3N2), and influenza B viruses are included in each year’s influenza vaccine. Getting a flu vaccine can protect against flu viruses that are the same or related to the viruses in the vaccine. The 2010-2011 flu vaccine will protect against 2009 H1N1, and two other influenza viruses (an H3N2 virus and an influenza B virus). The seasonal flu vaccine does not protect against influenza C viruses.

    • How the Flu Virus Can Change: "Drift" and "Shift"

      Influenza viruses can change in two different ways.

      One is called "antigenic drift." These are small changes in the virus that happen continually over time. Antigenic drift produces new virus strains that may not be recognized by the body's immune system. This process works as follows: a person infected with a particular flu virus strain develops antibody against that virus. As newer virus strains appear, the antibodies against the older strains no longer recognize the "newer" virus, and reinfection can occur. This is one of the main reasons why people can get the flu more than one time. In most years, one or two of the three virus strains in the influenza vaccine are updated to keep up with the changes in the circulating flu viruses. So, people who want to be protected from flu need to get a flu shot every year.

      The other type of change is called "antigenic shift." Antigenic shift is an abrupt, major change in the influenza A viruses, resulting in new hemagglutinin and/or new hemagglutinin and neuraminidase proteins in influenza viruses that infect humans. Shift results in a new influenza A subtype or a virus with a hemagglutinin or a hemagglutinin and neuraminidase combination that has emerged from an animal population that is so different from the same subtype in humans that most people do not have immunity to the new (e.g. novel) virus. Such a “shift” occurred in the spring of 2009, when a new H1N1 virus with a new combination of genes emerged to infect people and quickly spread, causing a pandemic. When shift happens, most people have little or no protection against the new virus. While influenza viruses are changing by antigenic drift all the time, antigenic shift happens only occasionally. Type A viruses undergo both kinds of changes; influenza type B viruses change only by the more gradual process of antigenic drift.

    • Images of Influenza Viruses

      These images provide a 3D graphical representation of the biology and structure of a generic influenza virus, and are not specific to the 2009 H1N1 virus.

                 

    • Transmission of Influenza Viruses from Animals to People

      Influenza A viruses are found in many different animals, including ducks, chickens, pigs, whales, horses and seals.

      Influenza B viruses circulate widely only among humans.

      Influenza A viruses are divided into subtypes based on two proteins on the surface of the virus: the hemagglutinin (H) and the neuraminidase (N). There are 16 different hemagglutinin subtypes and 9 different neuraminidase subtypes, all of which have been found among influenza A viruses in wild birds. Wild birds are the primary natural reservoir for all subtypes of influenza A viruses and are thought to be the source of influenza A viruses in all other animals. Most influenza viruses cause asymptomatic or mild infection in birds; however, the range of symptoms in birds varies greatly depending on the strain of virus. Infection with certain avian influenza A viruses (for example, some strains of H5 and H7 viruses) can cause widespread disease and death among some species of wild and especially domestic birds such as chickens and turkeys.

      Pigs can be infected with both human and avian influenza viruses in addition to swine influenza viruses. Infected pigs get symptoms similar to humans, such as cough, fever and runny nose. Because pigs are susceptible to avian, human and swine influenza viruses, they potentially may be infected with influenza viruses from different species (e.g., ducks and humans) at the same time. If this happens, it is possible for the genes of these viruses to mix and create a new virus. For example, if a pig were infected with a human influenza virus and an avian influenza virus at the same time, the viruses could mix (reassort) and produce a new virus that had most of the genes from the human virus, but a hemagglutinin and/or neuraminidase from the avian virus. The resulting new virus would likely be able to infect humans and spread from person to person, but it would have surface proteins (hemagglutinin and/or neuraminidase) not previously seen in influenza viruses that infect humans. This type of major change in the influenza A viruses is known as antigenic shift. Antigenic shift results when a new influenza A subtype to which most people have little or no immune protection infects humans. If this new virus causes illness in people and can be transmitted easily from person to person, an influenza pandemic can occur.

      While it is unusual for people to get influenza infections directly from animals, sporadic human infections and outbreaks caused by certain avian influenza A viruses have been reported.

      2009 influenza A (H1N1) is a new flu virus of swine origin that first caused illness in Mexico and the United States in March and April, 2009. This virus was originally referred to as “swine flu” because laboratory testing showed that many of the genes in this new virus were very similar to influenza viruses that normally occur in pigs (swine) in North America. But further study has shown that this new virus is very different from what normally circulates in North American pigs. It has two genes from flu viruses that normally circulate in pigs in Europe and Asia and bird (avian) genes and human genes. Scientists call this a "quadruple reassortant" virus.

    • 2009 H1N1 Influenza

      The U.S. Public Health Emergency for 2009 H1N1 Influenza expired on June 23, 2010. On August 10, 2010, the World Health Organization (WHO)External Web Site Icon International Health Regulations (IHR) Emergency Committee declared an end to the 2009 H1N1 pandemic globally. For information about CDC’s response to the 2009 H1N1 pandemic, visit The 2009 H1N1 Pandemic: Summary Highlights, April 2009-April 2010. Internationally, 2009 H1N1 viruses and seasonal influenza viruses are co-circulating in many parts of the world. It is likely that the 2009 H1N1 virus will continue to spread for years to come, like a regular seasonal influenza virus.

  • 4) Parainfluenza (Common cold and croup)

    Clinical features: Human parainfluenza viruses (HPIVs) are second to respiratory syncytial virus (RSV) as a common cause of lower respiratory tract disease in young children. Similar to RSV, HPIVs can cause repeated infections throughout life, usually manifested by an upper respiratory tract illness (e.g., a cold and/or sore throat). HPIVs can also cause serious lower respiratory tract disease with repeat infection (e.g., pneumonia, bronchitis, and bronchiolitis), especially among the elderly, and among patients with compromised immune systems. Each of the four HPIVs has different clinical and epidemiologic features. The most distinctive clinical feature of HPIV-1 and HPIV-2 is croup (i.e., laryngotracheobronchitis); HPIV-1 is the leading cause of croup in children, whereas HPIV-2 is less frequently detected. Both HPIV-1 and -2 can cause other upper and lower respiratory tract illnesses. HPIV-3 is more often associated with bronchiolitis and pneumonia. HPIV-4 is infrequently detected, possibly because it is less likely to cause severe disease. The incubation period for HPIVs is generally from 1 to 7 days.

    The viruses: HPIVs are negative-sense, single-stranded RNA viruses that possess fusion and hemagglutinin-neuraminidase glycoprotein "spikes" on their surface. There are four serotypes types of HPIV (1 through 4) and two subtypes (4a and 4b). The virion varies in size (average diameter between 150 and 300 nm) and shape, is unstable in the environment (surviving a few hours on environmental surfaces), and is readily inactivated with soap and water.

    Epidemiologic features: HPIVs are spread from respiratory secretions through close contact with infected persons or contact with contaminated surfaces or objects. Infection can occur when infectious material contacts mucous membranes of the eyes, mouth, or nose, and possibly through the inhalation of droplets generated by a sneeze or cough. HPIVs can remain infectious in aerosols for over an hour. HPIVs are ubiquitous and infect most people during childhood. The highest rates of serious HPIV illnesses occur among young children. Serologic surveys have shown that 90% to 100% of children aged 5 years and older have antibodies to HPIV- 3, and about 75% have antibodies to HPIV-1 and -2. The different HPIV serotypes differ in their clinical features and seasonality. HPIV-1 causes biennial outbreaks of croup in the fall (presently in the United States during odd numbered years). HPIV-2 causes annual or biennial fall outbreaks. HPIV-3 peak activity occurs during the spring and early summer months each year, but the virus can be isolated throughout the year.

    Diagnosis: Infection with HPIVs can be confirmed in two ways: 1) by isolation and identification of the virus in cell culture or by direct detection of the virus in respiratory secretions (usually, collected within one week of onset of symptoms) using immunofluorescence, enzyme immunoassay, or polymerase chin reaction assay, and 2) by demonstration of a significant rise in specific IgG antibodies between appropriately collected paired serum specimens or specific IgM antibodies in a single serum specimen.

    Prevention: No vaccine is currently available to protect against infection caused by any of the HPIVs; however, researchers are developing vaccines against HPIV-1 and -3 infections. Passively acquired maternal antibodies may play a role in protection from HPIV types 1 and 2 in the first few months of life, highlighting the importance of breast-feeding. Strict attention to infection-control practices should decrease or prevent spread of infection. Frequent handwashing and not sharing items such as cups, glasses, and utensils with an infected person should decrease the spread of virus to others. Excluding children with colds or other respiratory illnesses (without fever) who are well enough to attend child care or school settings will probably not decrease the spread of HPIVs, because the viruses are often spread in the early stages of illness. In a hospital setting, spread of HPIVs can and should be prevented by strict attention to contact precautions, such as handwashing and wearing of protective gowns and gloves.

  • 5) Bacteria, in rare cases
  • 6) Pollutants (airborne chemicals or irritants)
  • Signs and Symptoms of Bronchitis

    • Cough that produces mucus (may be without mucus the first few days)
    • Soreness in the chest
    • Fatigue
    • Mild headache
    • Mild body aches
    • Low-grade fever (less than 102°F)
    • Watery eyes
    • Sore throat

    See a Healthcare Provider if You or Your Child has:

    • Temperature higher than 100.4° F
    • A fever and cough with thick or bloody mucus
    • A chronic heart or lung problem
    • Shortness of breath or trouble breathing
    • Symptoms that last more than 3 weeks
    • Repeated episodes of bronchitis/bronchiolitis

    If your child is younger than three months of age and has a fever, it’s important to always call your healthcare provider right away.

    Your healthcare provider can determine if you or your child has acute bronchitis, chronic bronchitis, bronchiolitis, or another type of respiratory infection. Then a decision can be made about possible needed treatment.

    Antibiotics are Needed When…

    Antibiotics will rarely be needed since acute bronchitis and bronchiolitis are almost always caused by a virus and chronic bronchitis requires other therapies. However, treatment may be prescribed to relieve symptoms. If your healthcare provider diagnoses you or your child with another type of respiratory infection such as pneumonia (knew-MOHN-ya) or whooping cough (pertussis: purr-TUSS-uss), antibiotics will most likely be prescribed.

    Antibiotics Will Not Help if…

    When bronchitis is caused by a virus or irritation in the air (like cigarette smoke) , antibiotic treatment will not help it get better. Since acute bronchitis almost always gets better on its own, it is better to wait and take antibiotics only when they are needed. Taking antibiotics when they are not needed can be harmful.

    Each time you or your child takes an antibiotic, the bacteria that normally live in your body (on the skin, in the intestine, in the mouth and nose, etc.) are more likely to become resistant to antibiotics. Common antibiotics cannot kill infections caused by these resistant germs.

    Antibiotic Resistance

    Antibiotic resistance is the ability of bacteria or other microbes to resist the effects of an antibiotic. Antibiotic resistance occurs when bacteria change in some way that reduces or eliminates the effectiveness of drugs, chemicals, or other agents designed to cure or prevent infections. The bacteria survive and continue to multiply causing more harm.

    Antibiotic resistance has been called one of the world's most pressing public health problems. Almost every type of bacteria has become stronger and less responsive to antibiotic treatment when it is really needed. These antibiotic-resistant bacteria can quickly spread to family members, schoolmates, and co-workers - threatening the community with a new strain of infectious disease that is more difficult to cure and more expensive to treat. For this reason, antibiotic resistance is among CDC's top concerns.

    Antibiotic resistance can cause significant danger and suffering for children and adults who have common infections, once easily treatable with antibiotics. Microbes can develop resistance to specific medicines. A common misconception is that a person's body becomes resistant to specific drugs. However, it is microbes, not people, that become resistant to the drugs.

    If a microbe is resistant to many drugs, treating the infections it causes can become difficult or even impossible. Someone with an infection that is resistant to a certain medicine can pass that resistant infection to another person. In this way, a hard-to-treat illness can be spread from person to person. In some cases, the illness can lead to serious disability or even death.

    Antibiotic use promotes development of antibiotic-resistant bacteria. Every time a person takes antibiotics, sensitive bacteria are killed, but resistant germs may be left to grow and multiply. Repeated and improper uses of antibiotics are primary causes of the increase in drug-resistant bacteria.

    While antibiotics should be used to treat bacterial infections, they are not effective against viral infections like the common cold, most sore throats, and the flu. Widespread use of antibiotics promotes the spread of antibiotic resistance. Smart use of antibiotics is the key to controlling the spread of resistance.

    Antibiotic resistance occurs when bacteria change in some way that reduces or eliminates the effectiveness of drugs, chemicals, or other agents designed to cure or prevent infections. The bacteria survive and continue to multiply causing more harm. Bacteria can do this through several mechanisms. Some bacteria develop the ability to neutralize the antibiotic before it can do harm, others can rapidly pump the antibiotic out, and still others can change the antibiotic attack site so it cannot affect the function of the bacteria.

    Antibiotics kill or inhibit the growth of susceptible bacteria. Sometimes one of the bacteria survives because it has the ability to neutralize or escape the effect of the antibiotic; that one bacterium can then multiply and replace all the bacteria that were killed off. Exposure to antibiotics therefore provides selective pressure, which makes the surviving bacteria more likely to be resistant. In addition, bacteria that were at one time susceptible to an antibiotic can acquire resistance through mutation of their genetic material or by acquiring pieces of DNA that code for the resistance properties from other bacteria. The DNA that codes for resistance can be grouped in a single easily transferable package. This means that bacteria can become resistant to many antimicrobial agents because of the transfer of one piece of DNA.

    The Food and Drug Administration's (FDA's) Center for Veterinary Medicine (CVM) produced a nine-minute animation explaining how antimicrobial resistance both emerges and proliferates among bacteria. Over time, the use of antimicrobial drugs will result in the development of resistant strains of bacteria, complicating clinicians' efforts to select the appropriate antimicrobial for treatment.

    How to Feel Better

    Rest, over-the-counter medicines and other self-care methods may help you or your child feel better. Remember, always use over-the-counter products as directed. Many over-the-counter products are not recommended for children younger than certain ages.

    Children and adults with viral infections, which antibiotics cannot treat, usually recover when the illness has run its course. Colds, a type of viral infection, can last for up to two weeks. You should keep your healthcare provider informed if your or your child’s illness gets worse or lasts longer than expected. Over-the-counter medicines may help relieve some symptoms.

    For upper respiratory infections, such as sore throats, ear infections, sinus infections, colds, and bronchitis, try the following:

    For children and adults, over-the-counter pain relievers, decongestants and saline nasal sprays may help relieve some symptoms. Remember, always use over-the-counter products as directed. Many over-the-counter products are not recommended for children younger t han certain ages.

    Over-the-counter medicines may help relieve symptoms such as runny nose, congestion, fever and aches, but they do not shorten the length of time you or your child is sick.

    Learn more by reading below about over-the-counter medicines. Here are some helpful tips for how to feel better depending on how you or your child feels.

    Sore Throat

    • Soothe a sore throat with ice chips, sore throat spray, or lozenges (do not give lozenges to young children)
    • Use a clean humidifier or cool mist vaporizer

    • Take acetaminophen, ibuprofen or naproxen to relieve pain or fever

    Ear Pain

    • Put a warm moist cloth over the ear that hurts
    • Take acetaminophen, ibuprofen or naproxen to relieve pain or fever

    Runny Nose

    • Use a decongestant or saline nasal spray to help relieve nasal symptoms

    Sinus Pain/Pressure

    • Put a warm compress over the nose and forehead to help relieve sinus pressure
    • Use a decongestant or saline nasal spray
    • Breathe in steam from a bowl of hot water or shower
    • Take acetaminophen, ibuprofen or naproxen to relieve pain or fever

    Cough

    • Use a clean humidifier or cool mist vaporizer or breathe in steam from a bowl of hot water or shower.

      Parents might consider clearing nasal congestion in infants with a rubber suction bulb. Also, a stuffy nose can be relieved with saline nose drops.

      Cough and cold symptoms usually go away without treatment after a certain amount of time. Over-the-counter cough and cold medicines will not cure the common cold, but may give some temporary relief of symptoms. Parents should consult their child’s healthcare provider if they have any concerns or questions about giving their child a medication. Parents should always tell their child’s healthcare provider about all prescription and over-the-counter medicines they are giving their child.

      Some cough and cold medicines contain more than one active ingredient. Also, follow directions carefully to avoid giving too much medication; the right amount of medication often depends on your child’s age and weight.

    Over-the-Counter (OTC) Medicines

    For children and adults, over-the-counter pain relievers, decongestants and saline nasal sprays may help relieve some symptoms. Remember, always use over-the-counter products as directed. Not all products are recommended for children younger than certain ages. Overuse and misuse of OTC cough and cold medicines in young children can result in serious and potentially life-threatening side effects.

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    These medicines may help relieve symptoms such as runny nose, congestion, fever and aches, but they do not shorten the length of time you or your child is sick.

    Preventing Acute Bronchitis

    • Avoid smoking
    • Avoid exposure to second hand smoke and do not expose children to second hand smoke
    • Practice good hand hygiene
    • Keep you and your child up to date with recommended immunizations

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